Scientific evidence

Measured. Not claimed.

These studies examine exactly the bioactive peptides we use in our products.

Skin: what the trials measured

Based on placebo-controlled human studies using specific collagen peptides.

Research in this area examines fibroblasts — the cells involved in the skin’s own collagen processes — alongside elasticity and moisture measurements.

THESE RESULTS COME FROM STUDIES ON SPECIFIC BIOACTIVE PEPTIDES — NOT ON GENERIC COLLAGEN.

Measured outcomes, from controlled trials.

Documented results from placebo-controlled human studies using the same peptides we use in our products.

20%
20% reduction in eye wrinkle volume after 8 weeks vs. placebo
After 8 weeks vs. placebo
Proksch et al. 2014
8%
+7.6% better skin elasticity vs. placebo
After 12 weeks vs. placebo
Proksch et al. 2020
9%
−9% less cellulite in women of normal weight after 6 months vs. placebo
After 24 weeks vs. placebo
Schunck et al. 2015
Measured.Analysed.Reproducible.
Key study
Identical peptides
E. Proksch, M. Schunck, V. Zague, D. Segger, J. Degwert, S. Oesser

Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 114
Study duration 8 weeks
Key finding

"Statistically significant reduction in eye wrinkle volume after 8 weeks of daily intake of specific collagen peptides — measurable as early as 4 weeks, with a demonstrated lasting effect 4 weeks after intake ended."

Matching products
Hair, Skin, Nails Collagen Capsules Hair, Skin, Nails Collagen Capsules
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Hair, Skin, Nails Collagen Powder Hair, Skin, Nails Collagen Powder
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Identical peptides
Proksch E, Schunck M, Oesser S

Positive effect of fish-derived Bioactive Collagen Peptides on skin health

Study design placebo-controlled, randomised, peer-reviewed, ethics-approved
Sample N = 76
Study duration 12 weeks
Key finding

"Significant improvement in skin elasticity and reduction in eye wrinkle volume in women (50–70 years) after 8 weeks of daily intake of 5 g fish-based collagen peptides — effects persisting 4 weeks after intake ended."

Matching products Marine Collagen Powder - 100% pure → MARINE COLLAGEN POWDER - 100% PURE Marine Collagen Capsules → MARINE COLLAGEN CAPSULES
Identical peptides
Michael Schunck, Vivian Zague, Steffen Oesser, Ehrhardt Proksch

Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 105
Study duration 24 weeks
Key finding

"Statistically significant reduction in cellulite and skin unevenness on the thighs after 6 months of daily intake of specific collagen peptides — with a stronger effect in women of normal weight."

Matching products Hair, Skin, Nails Collagen Capsules → HAIR, SKIN, NAILS COLLAGEN CAPSULES Hair, Skin, Nails Collagen Powder → HAIR, SKIN, NAILS COLLAGEN POWDER

Hair: thickness and density in trials

Based on placebo-controlled human studies using specific collagen peptides.

These trials look at hair follicle cells and the body’s own hair growth cycle.

THESE RESULTS COME FROM STUDIES ON SPECIFIC BIOACTIVE PEPTIDES — NOT ON GENERIC COLLAGEN.

Measured outcomes, from controlled trials.

Documented results from placebo-controlled human studies using the same peptides we use in our products.

31%
+31% more growth activity in the hair roots after 16 weeks vs. placebo
After 16 weeks vs. placebo
Oesser 2020
45%
−44.6% less collagen breakdown in the skin after 12 weeks vs. placebo
After 12 weeks vs. placebo
Reilly et al. 2024
Measured.Analysed.Reproducible.
Key study
Identical peptides
Steffen Oesser

The Oral Intake of Specific Bioactive Collagen Peptides Has a Positive Effect on Hair Thickness

Study design placebo-controlled, randomised, peer-reviewed, ethics-approved
Sample N = 44
Study duration 16 weeks
Key finding

"Statistically significant increase in hair thickness and hair follicle cell proliferation after 16 weeks of daily intake of 2.5 g specific collagen peptides."

Matching products
Hair, Skin, Nails Collagen Powder Hair, Skin, Nails Collagen Powder
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Hair, Skin, Nails Collagen Capsules Hair, Skin, Nails Collagen Capsules
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Comparable peptides
David M. Reilly, Liane Kynaston, Salma Naseem, Eva Proudman, Darcy Laceby

A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 130
Study duration 12 weeks
Key finding

"Significant improvement in skin elasticity, hydration and wrinkle reduction as well as visibly healthier hair in adults (40–60 years) after 12 weeks of daily intake of marine collagen with vitamin C."

Nails: growth rate and breakage

Based on placebo-controlled human studies using specific collagen peptides.

The trials recorded nail growth rate and how often nails broke, over 24 weeks.

THESE RESULTS COME FROM STUDIES ON SPECIFIC BIOACTIVE PEPTIDES — NOT ON GENERIC COLLAGEN.

Measured outcomes, from controlled trials.

Documented results from placebo-controlled human studies using the same peptides we use in our products.

12%
+12% faster nail growth after 24 weeks
After 24 weeks vs. placebo
Hexsel et al. 2017
45%
−44.6% less collagen breakdown in the skin after 12 weeks vs. placebo
After 12 weeks vs. placebo
Reilly et al. 2024
Measured.Analysed.Reproducible.
Key study
Identical peptides
Doris Hexsel, Vivian Zague, Michael Schunck, Carolina Siega, Fernanda O. Camozzato, Steffen Oesser

Oral Supplementation with Specific Bioactive Collagen Peptides Improves Nail Growth and Reduces Symptoms of Brittle Nails

Study design peer-reviewed, ethics-approved
Sample N = 25
Study duration 24 weeks
Key finding

"Statistically significant improvement in nail growth and a clear reduction in brittle-nail symptoms after 24 weeks of daily intake of specific collagen peptides — with a lasting effect 4 weeks after intake ended."

Matching products
Hair, Skin, Nails Collagen Powder Hair, Skin, Nails Collagen Powder
Learn more →
Hair, Skin, Nails Collagen Capsules Hair, Skin, Nails Collagen Capsules
Learn more →
Comparable peptides
David M. Reilly, Liane Kynaston, Salma Naseem, Eva Proudman, Darcy Laceby

A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 130
Study duration 12 weeks
Key finding

"Significant improvement in skin elasticity, hydration and wrinkle reduction as well as visibly healthier hair in adults (40–60 years) after 12 weeks of daily intake of marine collagen with vitamin C."

Joints: mobility and discomfort scores

Based on placebo-controlled human studies using specific collagen peptides.

Research here examines chondrocytes — the cells that maintain cartilage — alongside participants’ own mobility scores.

THESE RESULTS COME FROM STUDIES ON SPECIFIC BIOACTIVE PEPTIDES — NOT ON GENERIC COLLAGEN.

Measured outcomes, from controlled trials.

Documented results from placebo-controlled human studies using the same peptides we use in our products.

38%
−38% less knee pain during sport after 12 weeks vs. placebo
After 12 weeks vs. placebo
Zdzieblik et al. 2017
40%
−40% less knee pain during sport after 12 weeks vs. placebo
After 12 weeks vs. placebo
Zdzieblik et al. 2021
38%
−38% less joint pain when walking after 12 weeks vs. placebo
After 12 weeks vs. placebo
Schulze et al. 2016
Measured.Analysed.Reproducible.
Key study
Identical peptides
Denise Zdzieblik, Steffen Oesser, Albert Gollhofer, Daniel König

Improvement of Activity-Related Knee Joint Discomfort Following Supplementation of Specific Collagen Peptides

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 139
Study duration 12 weeks
Key finding

"Statistically significant reduction in activity-related knee pain in athletes after 12 weeks of daily intake of specific collagen peptides — confirmed both by the participants themselves and by physician assessment."

Matching products
Collagen Capsules for Joints and Cartilage Collagen Capsules for Joints and Cartilage
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Collagen Powder for Joints and Cartilage Collagen Powder for Joints and Cartilage
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Identical peptides
Denise Zdzieblik, Judith Brame, Steffen Oesser, Albert Gollhofer, Daniel König

The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 180
Study duration 12 weeks
Key finding

"Significant reduction in activity-related knee pain in young athletes (18–30 years) after 12 weeks of daily intake of specific collagen peptides — confirming the results of an earlier study in a larger group."

Matching products Collagen Capsules for Joints and Cartilage → COLLAGEN CAPSULES FOR JOINTS AND CARTILAGE Collagen Powder for Joints and Cartilage → COLLAGEN POWDER FOR JOINTS AND CARTILAGE
Identical peptides
C.H. Schulze, Denise Zdzieblik, Steffen Oesser, Albert Gollhofer, Daniel König

Efficacy of Specific Bioactive Collagen Peptides in the Treatment of Joint Pain – Study in Adults with Functional Joint Discomfort

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 182
Study duration 12 weeks
Key finding

"Statistically significant reduction in everyday knee and hip joint pain in adults (mean age 50) after 12 weeks of daily intake of specific collagen peptides."

Matching products Collagen Capsules for Joints and Cartilage → COLLAGEN CAPSULES FOR JOINTS AND CARTILAGE Collagen Powder for Joints and Cartilage → COLLAGEN POWDER FOR JOINTS AND CARTILAGE

Bone: density measured over 12 months

Based on placebo-controlled human studies using specific collagen peptides.

These studies measure bone mineral density, and examine osteoblasts — the cells that build bone tissue.

THESE RESULTS COME FROM STUDIES ON SPECIFIC BIOACTIVE PEPTIDES — NOT ON GENERIC COLLAGEN.

Measured outcomes, from controlled trials.

Documented results from placebo-controlled human studies using the same peptides we use in our products.

4%
+4.3% more bone density in the spine after 12 months vs. placebo
After 52 weeks vs. placebo
König et al. 2018
6%
+5.79% more bone density in the spine after 4 years (continuous-intake group)
After 208 (4 years) weeks vs. placebo
Zdzieblik et al. 2021
6%
+5.79% more bone density in the spine after 4 years (continuous-intake group)
After 208 (4 years) weeks vs. placebo
Zdzieblik et al. 2021
Measured.Analysed.Reproducible.
Key study
Identical peptides
Daniel König, Steffen Oesser, Stephan Scharla, Denise Zdzieblik, Albert Gollhofer

Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women – A Randomized Controlled Study

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 131
Study duration 52 weeks
Key finding

"Statistically significant improvement in bone density at the spine and hip after 12 months of daily intake of specific collagen peptides — while bone density declined in the placebo group."

Matching products
Bone Health Collagen Capsules Bone Health Collagen Capsules
Learn more →
Bone Health Collagen Powder Bone Health Collagen Powder
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Identical peptides
Denise Zdzieblik, Steffen Oesser, Daniel König

Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women

Study design peer-reviewed, ethics-approved
Sample N = 31
Study duration 208 (4 years) weeks
Key finding

"Continuous increase in bone density at the spine and hip after 4 years of daily intake of specific collagen peptides — follow-up to the main study with 31 postmenopausal women."

Matching products Bone Health Collagen Powder → BONE HEALTH COLLAGEN POWDER Bone Health Collagen Capsules → BONE HEALTH COLLAGEN CAPSULES
Identical peptides
Denise Zdzieblik, Steffen Oesser, Daniel König

Specific Bioactive Collagen Peptides in Osteopenia and Osteoporosis: Long-Term Observation in Postmenopausal Women

Study design peer-reviewed, ethics-approved
Sample N = 31
Study duration 208 (4 years) weeks
Key finding

"Continuous increase in bone density at the spine and hip after 4 years of daily intake of specific collagen peptides — follow-up to the main study with 31 postmenopausal women."

Matching products Bone Health Collagen Powder → BONE HEALTH COLLAGEN POWDER Bone Health Collagen Capsules → BONE HEALTH COLLAGEN CAPSULES

Muscle: body composition with resistance training

Based on placebo-controlled human studies using specific collagen peptides.

These trials combine daily intake with resistance training and measure body composition and physical performance.

THESE RESULTS COME FROM STUDIES ON SPECIFIC BIOACTIVE PEPTIDES — NOT ON GENERIC COLLAGEN.

Measured outcomes, from controlled trials.

Documented results from placebo-controlled human studies using the same peptides we use in our products.

4%
+4.2 kg muscle mass vs. +2.9 kg (placebo) after 12 weeks
After 12 weeks vs. placebo
Zdzieblik et al. 2015
61%
+61% more growth in the inner thigh muscle after 15 weeks vs. placebo (by MRI)
After 15 weeks vs. placebo
Balshaw et al. 2022
3%
+3.42 kg fat-free mass in the collagen group vs. +1.83 kg (placebo) and +2.27 kg (whey) after 12 weeks
After 12 weeks vs. placebo
Zdzieblik et al. 2021
Measured.Analysed.Reproducible.
Key study
Comparable peptides
Denise Zdzieblik, Steffen Oesser, Manfred W. Baumstark, Albert Gollhofer, Daniel König

Collagen Peptide Supplementation in Combination with Resistance Training Improves Body Composition and Increases Muscle Strength in Elderly Sarcopenic Men: A Randomised Controlled Trial

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 53
Study duration 12 weeks
Key finding

"Significant improvement in muscle mass and muscle strength in older men with sarcopenia (mean age 72) after 12 weeks of resistance training with daily intake of specific collagen peptides."

Comparable peptides
Thomas G. Balshaw, Mark P. Funnell, Emmet McDermott, Thomas M. Maden-Wilkinson, Sean Abela, Btool Quteishat, Max Edsey, Lewis J. James, Jonathan P. Folland

The Effect of Specific Bioactive Collagen Peptides on Function and Muscle Remodeling During Human Resistance Training

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 39
Study duration 15 weeks
Key finding

"First MRI-based study with direct evidence of significantly greater muscle growth in young men after 15 weeks of resistance training with daily intake of specific collagen peptides."

Comparable peptides
Denise Zdzieblik, Patrick Jendricke, Steffen Oesser, Albert Gollhofer, Daniel König

The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 97
Study duration 12 weeks
Key finding

"Significantly greater increase in muscle mass and reduction in body fat in middle-aged, untrained men (30–60 years) after 12 weeks of resistance training with daily intake of specific collagen peptides — with a stronger effect than whey protein and placebo."

Vegetarian: skin and connective tissue trials

Based on placebo-controlled human studies using specific bioactive ingredients.

The trials measured skin elasticity, firmness and barrier function.

THESE RESULTS COME FROM STUDIES ON SPECIFIC BIOACTIVE INGREDIENTS — NOT ON GENERIC COLLAGEN.

Measured outcomes, from controlled trials.

Documented results from placebo-controlled human studies using the same peptides we use in our products.

25%
+25% better skin elasticity after 60 days vs. placebo
After 8 weeks vs. placebo
Gil-Quintana et al. 2018
Measured.Analysed.Reproducible.
Key study
Identical peptides
Erena Gil-Quintana, Manuel La Nuez, Andrés Aguirre

Supplementation with Ovoderm® Reduces the Clinical Signs of Skin Aging. A Double-Blind, Placebo-Controlled Study

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 50
Study duration 8 weeks
Key finding

"Significant improvement in skin elasticity and firmness and a reduction in moisture loss in healthy participants (45–75 years) after 60 days of daily intake of 300 mg eggshell membrane extract vs. placebo."

Matching products
Vegetarian Collagen Complex with hyaluron and elastin Vegetarian Collagen Complex with hyaluron and elastin
Learn more →
Identical peptides
Eggnovo / Korea Food Research Institute

Effects of Oral Supplementation with Eggshell Membrane (Ovoderm®-AS) on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Trial

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 85
Study duration 12 weeks
Key finding

"Significant improvement in wrinkles, elasticity, skin density, hydration and transepidermal water loss in women (25–60 years) after 12 weeks of daily intake of 600 mg eggshell membrane extract — first improvements after just 6 weeks."

Matching products Vegetarian Collagen Complex with hyaluron and elastin → VEGETARIAN COLLAGEN COMPLEX WITH HYALURON AND ELASTIN
Identical peptides
Eggnovo / Korea Food Research Institute

Effects of Oral Supplementation with Eggshell Membrane (Ovoderm®-AS) on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Trial

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 85
Study duration 12 weeks
Key finding

"Significant improvement in wrinkles, elasticity, skin density, hydration and transepidermal water loss in women (25–60 years) after 12 weeks of daily intake of 600 mg eggshell membrane extract — first improvements after just 6 weeks."

Matching products Vegetarian Collagen Complex with hyaluron and elastin → VEGETARIAN COLLAGEN COMPLEX WITH HYALURON AND ELASTIN

Vegan: a comparable-collagen trial

Based on a placebo-controlled human study using a comparable vegan collagen.

The trial measured skin elasticity, collagen density and wrinkle depth.

THESE RESULTS COME FROM ONE STUDY ON A COMPARABLE VEGAN COLLAGEN — NOT ON IDENTICAL INGREDIENTS.

Measured outcomes, from controlled trials.

Documented results from placebo-controlled human studies using the same peptides we use in our products.

28%
−27.5% fewer wrinkles after 8 weeks vs. placebo
After 8 weeks vs. placebo
Lin et al. 2023
31%
−31% collagen breakdown in the dermis after 12 weeks vs. placebo
After 12 weeks vs. placebo
Asserin et al. 2015
45%
−44.6% less collagen breakdown in the skin after 12 weeks vs. placebo
After 12 weeks vs. placebo
Reilly et al. 2024
Measured.Analysed.Reproducible.
Key study
Comparable peptides
Yung-Kai Lin, Chia-Hua Liang, Yung-Hsiang Lin, Tai-Wen Lin, Josué Jiménez Vázquez, Anthony van Campen, Chi-Fu Chiang

Oral Supplementation of Vegan Collagen Biomimetic Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 90
Study duration 8 weeks
Key finding

"Significant improvement in wrinkles, skin texture, pores, skin elasticity, skin collagen density and hydration in 30 participants after 8 weeks of daily intake of 5 g vegan collagen biomimetic — results comparable to fish collagen in the same study."

Comparable peptides
Jérôme Asserin, Elian Lati, Toshiaki Shioya, Janne Prawitt

The Effect of Oral Collagen Peptide Supplementation on Skin Moisture and the Dermal Collagen Network – Study 2 (France)

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 106
Study duration 12 weeks
Key finding

"31% reduction in dermal collagen fragmentation and significant improvement in skin hydration in women (40–65 years) after 12 weeks of daily intake of 10 g fish collagen peptides."

Comparable peptides
David M. Reilly, Liane Kynaston, Salma Naseem, Eva Proudman, Darcy Laceby

A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen

Study design placebo-controlled, randomised, double-blind, peer-reviewed, ethics-approved
Sample N = 130
Study duration 12 weeks
Key finding

"Significant improvement in skin elasticity, hydration and wrinkle reduction as well as visibly healthier hair in adults (40–60 years) after 12 weeks of daily intake of marine collagen with vitamin C."

Scientific standards

Study criteria

We include only studies that meet our scientific standards — for the strongest available evidence.

  • Peer-reviewed human studies
  • Randomised, controlled study designs
  • Measurable, clinically relevant outcomes
  • Published in recognised journals

All linked studies are peer-reviewed and publicly accessible (PubMed / PMC). This page is for information only and does not replace medical advice.

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